Pharmacogenetics of Nitrous Oxide
نویسندگان
چکیده
منابع مشابه
Pharmacogenetics of nitrous oxide: standing at the crossroads.
IT has long been known that nitrous oxide in clinically relevant doses and durations shuts down single carbon pathways by virtue of oxidation of the cobalamin cofactor of methionine synthase, the sole occupant at the crossroads of the methylation, transsulfuration, and folate cycles. Surprisingly, the clinical consequences of nitrous oxide–mediated, folate–cobalamin cycle inactivation have not ...
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Nitrous oxide was an anaesthetic gas that was used for many years. There were many anaesthetic drugs in operations with many side effects. Nitrous oxide had some side effects too. But it was a safe gas in many times. In hospital personnel who worked in operating rooms exposure to this gas was important. The objective of this study was the introduction of nitrous oxide and neurologic side ...
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The diagnosis of a left-to-right shunt generally depends upon the demonstration of significant differences in oxygen content among the venae cavae, the chambers of the right heart, and the pulmonary artery. The inconclusive or misleading results sometimes obtained with this method have stimulated interest in improved technics. The wide arteriovenous difference that normally exists during the in...
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1258 June 2013 NITROUS oxide has long been known to be an impotent and unpredictable human anesthetic.1 In this issue of the journal, Chen et al.2 report that nitrous oxide in clinical use is a potent and predictable human genotoxin. The authors observe that maintenance of anesthesia with 70% nitrous oxide and sevoflurane in patients undergoing colorectal surgery doubles the incidence of DNA da...
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Myelo-cytotoxicity of extended nitrous oxide (N,O) inhalation was described almost forty years ago and then incidentally applied already with temporary success for suppressing leukemia. In 1948 the accompanying megaloblastic maturation arrest was explained by inactivation of the methylcobalamin coenzyme and subsequent folate deficiency. We studied the anti-leukemic effect of N, O on a transplan...
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ژورنال
عنوان ژورنال: Anesthesiology
سال: 2008
ISSN: 0003-3022
DOI: 10.1097/aln.0b013e31817be99e